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histidine ammonialyase : ウィキペディア英語版 | histidine ammonialyase
Histidine ammonia-lyase (or histidase, or histidinase) is an enzyme that in humans is encoded by the ''HAL'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3034 )〕 Histidase converts histidine into ammonia and urocanic acid. == Function ==
Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid.〔 The reaction is catalyzed by an electrophilic co-factor which is formed autocatalytically by cyclization of the protein backbone of the enzyme.
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